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KMID : 0377519810060040551
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 4 p.551 ~ p.559
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Carcinogenesis of N-2-Fluorenylacetamide in ICR Newborn Mice
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Kim Moo-Chul
Kang Sang-Kyoon
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Abstract
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This experiment was carried out to evaluate the tumor incidence in ICR newborn mice using N-2- fluorenylacetamide (FAA). FAA in 1% aquous gelatin was injected subcutaneously on the subscapular region of ICR newborn mice once daily during the first five days of life. Gross examination of viscerae was performed immediately after being sacrificed at 68th week of birth. Following results were obtained. 1. The weaning rates of 1% aquous gelatin control group and FAA-treated group were 97.5% and 83.6%, respectively. In refer to gelatin control group, weaning rate of FAA-treated group was decreased by 9%. 2. Survival rate at 68th week showed 55% in normal control group and 52% in gelatin-treated group, while in FAA-treated group showed 69%. 3. The statistical analysis of body weight of FAA-treated animal does not show significant deviation from the non-treated controls. However, FAA-treated male mice showed a slight increment in weight at 34th week of birth as a result of enhanced development of hepatoma and lung adenoma. 4. There were no significant difference of organ weight between control and FAA-treated groups except liver and lung, Increased weighs of liver and lung was seen in FAA-treated group due to development of hepatoma and adenoma. 5. Pulmonary adenoma and hepatoma were seen in FAA-treated mice at 68th week of birth. The incidence of pulmonary adenoma was 1% in normal and 11% in gelatin-treated groups, while FAA-treated group showed 18%. No hepatoma development was identified in normal, gelatin-treated group and in female mice ’th FAA-treated group. On the other hand, hepatoma developed in male FAA-treated mice with wi incidence of 64%.
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